Research Articles
The Uncultured Majority: Navigating the Challenges and Opportunities in Prokaryotic Taxonomy for Drug Discovery
The vast majority of prokaryotes resist cultivation in the laboratory, creating a fundamental challenge for taxonomy and limiting access to a potential treasure trove of novel natural products.
Bayesian Frameworks for Regulon Prediction: Integrating Computational Biology and Multi-Omics Data
This article provides a comprehensive overview of Bayesian probabilistic frameworks for elucidating regulons—groups of co-regulated operons—in microbial genomes.
Advanced Synthetic Biology Approaches for Prokaryotic Gene Cluster Engineering: From Discovery to Biomedical Applications
This article provides a comprehensive overview of contemporary synthetic biology strategies for engineering prokaryotic gene clusters, with a focus on addressing the critical need for novel bioactive compounds, particularly antibiotics.
Gene-Centered Frameworks for Prokaryotic Regulon Analysis: From Foundational Concepts to Biomedical Applications
This article provides a comprehensive overview of the paradigm shift from operon-centric to gene-centered frameworks in prokaryotic regulon analysis.
High-Throughput Transcriptomics in Prokaryotes: From RNA-Seq to Functional Insights in Drug Discovery
This article provides a comprehensive overview of high-throughput transcriptomics technologies and their application to prokaryotic systems.
Position-Specific Weight Matrices: From Theory to Practice in Prokaryotic Promoter Prediction
This article provides a comprehensive analysis of position-specific weight matrices (PWMs) and their application in predicting prokaryotic promoters.
Average Nucleotide Identity (ANI): The Genomic Gold Standard for Prokaryotic Species Delineation in Modern Research
This article provides a comprehensive resource for researchers and biotechnology professionals on the application of Average Nucleotide Identity (ANI) in prokaryotic species delineation.
Reconstructing Prokaryotic Regulons: A Comparative Genomics Guide for Decoding Transcriptional Networks
This article provides a comprehensive overview of the computational reconstruction of prokaryotic transcriptional regulatory networks using comparative genomics.
A Researcher's Guide to Comparative Genomics Tools for Prokaryotic Analysis
This article provides a comprehensive guide to the current landscape of computational tools for prokaryotic comparative genomics, tailored for researchers and drug development professionals.
Genomic SELEX: Unraveling Transcription Factor Binding Sites for Precision Drug Discovery
This article provides a comprehensive overview of genomic SELEX (Systematic Evolution of Ligands by Exponential Enrichment), a powerful high-throughput method for identifying transcription factor (TF) binding specificities.